PUBLICATIONS of Ishikawa Group (Telomere, Low-dose stress, Senescence)
Original articles
I. Yamamoto, H. Nakaoka, M. Takikawa, S. Tashiro, J. Kanoh, T. Miyoshi and F. Ishikawa. Fission yeast Stn1 maintains stability of repetitive DNA at subtelomere and ribosomal DNA regions. Nucleic Acids Res. 2021 Sep 14;gkab767.[NAR]
S. Ishikawa and F. Ishikawa. Proteostasis failure and cellular senescence in long-term cultured postmitotic rat neurons. Aging Cell. 2020 Jan;19(1):e13071. [Aging Cell]
H. Irie, I. Yamamoto, Y. Tarumoto, S. Tashiro, K.W. Runge, F. Ishikawa. Telomere-binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast. PLoS Genet 15(8): e1008335. [PLoS]
Takikawa M., Y. Tarumoto, and F. Ishikawa. Fission yeast Stn1 is crucial for semi-conservative replication at telomeres and subtelomeres. Nucleic Acids Res., 45(3):1255-1269 (2017). [NAR]
Hirai Y., M. Tamura, J. Otani, and F. Ishikawa. NEK6-mediated phosphorylation of human TPP1 regulates telomere length through telomerase recruitment. Genes Cells., 21 (8):874-889 (2016). [Wiley Interscience]
Wakai M., S. Abe, Y. Kazuki, M. Oshimura, and F. Ishikawa. A human artificial chromosome recapitulates the metabolism of native telomeres in mammalian cells. PLoS One, 9 (2):e88530 (2014). [PLoS One]
Nishiyama A., L. Yamaguchi, J. Sharif, Y. Johmura, T. Kawamura, K. Nakanishi, S. Shimamura, K. Arita, T. Kodama, F. Ishikawa, H. Koseki, and M. Nakanishi. Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication. Nature, 502 (7470):249-253 (2013). [Nature]
Tarumoto Y., J. Kanoh, and F. Ishikawa. Receptor for activated C-kinase (RACK1) homolog Cpc2 facilitates the general amino acid control response through Gcn2 kinase in fission yeast. J. Biol. Chem., 288 (26):19260-19268 (2013). [JBC]
Tashiro S., T. Asano, J. Kanoh, and F. Ishikawa. Transcription-induced chromatin association of RNA surveillance factors mediates facultative heterochromatin formation in fission yeast. Genes Cells., 18 (4):327-339 (2013). [Wiley Interscience]
Tanimura N., M. Saito, M. Ebisuya, E. Nishida, and F. Ishikawa. Stemness-related factor Sall4 interacts with transcription factors Oct-3/4 and Sox2 and occupies Oct-Sox elements in mouse embryonic stem cells. J. Biol. Chem., 288 (7):5027-5038 (2013). [JBC]
Fujita I., Y. Nishihara, M. Tanaka, H. Tsuji, Y. Chikashige, Y. Watanabe, M. Saito, F. Ishikawa, Y. Hiraoka, and J. Kanoh. Telomere-nuclear envelope dissociation promoted by Rap1 phosphorylation ensures faithful chromosome segregation. Curr. Biol., 22 (20):1932-1937 (2012). [Current Biology]
Yagi T., A. Kosakai, D. Ito, Y. Okada, W. Akamatsu, Y. Nihei, A. Nabetani, F. Ishikawa. Y. Arai, N. Hirose, H. Okano and N. Suzuki. Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research. PLoS One, 7 (7):e41572 (2012). [PLoS One]
Chujo M., Y. Tarumoto, K. Miyatake, E. Nishida and F. Ishikawa. HIRA, a conserved histone chaperone plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast. J. Biol. Chem., 287 (28):23440-23450 (2012). [JBC]
Hirai Y., K. Masutomi and F. Ishikawa. Kinetics of DNA replication and telomerase reaction at a single-seeded telomere in human cells. Genes Cells, 17 (3):186-204 (2012). [Wiley Interscience]
Yamazaki H., Y. Tarumoto and F. Ishikawa. Tel1ATM and Rad3ATR phosphorylate the telomere protein Ccq1 to recruit telomerase and elongate telomeres in fission yeast. Genes Dev., 26 (3):241-246 (2012). [CSH press]
Nakaoka H., A. Nishiyama, M. Saito and F. Ishikawa. Xenopus laevis Ctc1-Stn1-Ten1 (xCST) complex is involved in priming DNA synthesis on single-stranded DNA template in Xenopus egg extract. J. Biol. Chem., 287 (1):619-627 (2012). [JBC]
Muraki K., A. Nabetani, A. Nishiyama, and F. Ishikawa. Essential roles of Xenopus TRF2 in telomere end protection and replication. Genes Cells, 16 (6):728-739 (2011). [Wiley Interscience]
Asano K., M. Komatsu, Y. Yamaguchi-Iwai, F. Ishikawa, N. Mizushima, and K. Iwai. Distinct mechanisms of ferritin delivery to lysosomes in iron-depleted and iron-replete cells. Mol. Cell. Biol., 31 (10):2040-2052 (2011). [MCB]
Mikawa T., J. Kanoh, and F. Ishikawa. Fission yeast Vps1 and Atg8 contribute to oxidative stress resistance. Genes Cells, 15 (3):229-242 (2010). [Wiley Interscience]
Miyake Y., M. Nakamura, A. Nabetani, S. Shimamura, M. Tamura, S. Yonehara, M. Saito, and F. Ishikawa. RPA-like mammalian Ctc1-Stn1-Ten1 complex binds to single-stranded DNA and protects telomeres independently of the Pot1 pathway. Mol Cell, 36(2):193-206 (2009). [Molecular Cell]
Minamino T., M. Orimo, I. Shimizu, T. Kunieda, M. Yokoyama, T. Ito, A. Nojima, A. Nabetani, Y. Oike, H. Matsubara, F. Ishikawa, and I. Komuro. A critical role for adipose tissue p53 in the regulation of insulin resistance.Nat Med, 15(9):1082-1087 (2009). [PubMed]
Miyoshi T., J. Kanoh, and F. Ishikawa. Fission yeast Ku protein is required for recovery from DNA replication stress.Genes Cells, 14(9):1091-1103 (2009). [PubMed]
Kiriyama M., Y. Kobayashi, M. Saito, F. Ishikawa, and S. Yonehara. Interaction of FLASH with arsenite resistance protein 2 is involved in cell cycle progression at S phase.Mol. Cell. Biol., 29(17):4729-4741 (2009). [PubMed]
Nabetani A. and F. Ishikawa. Unusual telomeric DNAs in human telomerase-negative immortalized cells.Mol. Cell. Biol., 29(3):703-713 (2009). [PubMed]
Shimamura S. and F. Ishikawa. Interaction between DNMT1 and DNA replication reactions in the SV40 in vitro replication system.Cancer Sci., 99(10):1960-1966 (2008). [Wiley Interscience]
Satoh D., D. Sato, T. Tsuyama, M. Saito, H. Ohkura, M. M. Rolls, F. Ishikawa, and T. Uemura. Spatial control of branching within dendritic arbors by dynein-dependent transport of Rab5-endosomes. Nat. Cell Biol., 10(10):1164-1171 (2008). [PubMed]
Miyoshi T., J. Kanoh, M. Saito, and F. Ishikawa. Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.Science, 320(5881):1341-1344 (2008). [PubMed]
Fujikawa M., T. Katagiri, A. Tugores, Y. Nakamura, and F. Ishikawa. ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence.Cancer Sci., 98(9):1468-1475 (2007). [PubMed]
Lee J., Y. H. Sung, C. Choeong, Y. S. Choi, H. K. Jeon, W. Sun, W. C. Hahn, F. Ishikawa, and H. W. Lee. TERT promotes cellular and organismal survival independently of telomerase activity.Oncogene, 27(26):3754-3760 (2008). [PubMed]
Shikata M., F. Ishikawa and J. Kanoh.Tel2 is required for activation of the Mrc1-mediated replication checkpoint.J. Biol. Chem., 282(8):5346-5355 (2007). [PubMed]
Liu T., M. J. Chung, M. Ullenbruch, H. Yu, H. Jin, B. Hu, Y. Y. Choi, F. Ishikawa and S. H. Phan. Telomerase activity is required for bleomycin-induced pulmonar8+/y fibrosis in mice.J. Clin. Invest., 117(12):3800-3809 (2007). [PubMed]
Hayakawa T., Y. Ohtani, N. Hayakawa, K. Shinmyozu, M. Saito, F. Ishikawa, and J. Nakayama. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.Genes Cells, 12(6):811-826 (2007). [PubMed]
Funayama R., M. Saito, H. Tanobe and F. Ishikawa. Loss of linker histone H1 in cellular senescence.J. Cell Biol., 175(6):869-880 (2006). [PubMed]
Tsumura A., T. Hayakawa, Y. Kumaki, S. Takebayashi, M. Sakaue, C. Matsuoka, K. Shimotohno, F. Ishikawa, E. Li, H. R. Ueda, J. Nakayama and M. Okano. Maintenance of self-renewal ability of mouse embryonic stem cells in the absence of DNA methyltransferases Dnmt1, Dnmt3a and Dnmt3b.Genes Cells, 11(7):805-814 (2006). [PubMed]
Nishiyama A., K. Muraki, M. Saito, K. Ohsumi, T. Kishimoto and F. Ishikawa. Cell-cycle-dependent Xenopus TRF1 recruitment to telomere chromatin regulated by Polo-like kinase.EMBO J., 25(3):575-584 (2006). [PubMed]
Nakamura M., A. Nabetani, T. Mizuno, F. Hanaoka and F. Ishikawa. Alterations of DNA and chromatin structures at telomeres, and genetic instability in mouse cells defective in DNA polymerase α.Mol. Cell. Biol., 25(24):11073-11088 (2005). [PubMed]
Kanoh J., M. Sadaie, T. Urano and F. Ishikawa. Telomere binding protein Taz1 establishes Swi6 heterochromatin independently of RNAi at telomeres.Curr. Biol., 15(20):1808-1819 (2005). [PubMed]
Enokizono Y., Y. Konishi, K. Nagata, K. Ouhashi, S. Uesugi, F. Ishikawa and M. Katahira. Structure of hnRNP D complexed with single-stranded telomere DNA and unfolding of the quadruplex by heterogeneous nuclear ribonucleoprotein D.J. Biol. Chem., 280(19):18862-18870 (2005). [PubMed]
Okumura-Nakanishi S., M. Saito, H. Niwa and F. Ishikawa. Oct-3/4 and sox2 regulate oct-3/4 gene in embryonic stem cells.J. Biol. Chem., 280(7):5307-5317 (2005). [PubMed]
Nabetani A., O. Yokoyama and F. Ishikawa. Localization of hRad9, hHus1, hRad1, and hRad17 and caffeine-sensitive DNA replication at the alternative lengthening of telomeres-associated promyelocytic leukemia body.J. Biol. Chem., 279(24):25849-25857 (2004). [PubMed]
Ohki R. and F. Ishikawa. Telomere-bound TRF1 and TRF2 stall the replication fork at telomeric repeats.Nucleic Acids Res., 32(5):1627-1637 (2004). [PubMed]
Yoshimura S.H., H. Maruyama, R. Ohki, F. Ishikawa and K. Takeyasu. Molecular mechanism of DNA end-loop formation by TRF2.Genes Cells, 9(3):205-218 (2004). [PubMed]
Sadaie M., T. Naito and F. Ishikawa. Stable inheritance of telomere chromatin structure and function in the absence of telomeric repeats.Genes Dev., 17(18):2271-2282 (2003). [PubMed]
Kanoh J., S. Francesconi, A. Collura, V. Schramke, F. Ishikawa, G. Baldacci and V. Geli. The fission yeast spSet1p is a histone H3-K4 methyltransferase that functions in telomere maintenance and DNA repair in an ATM kinase Rad3-dependent pathway. J. Mol. Biol., 326(4):1081-1094 (2003). [PubMed]
Iwasa H., J. Han and F. Ishikawa. Mitogen-activated protein kinase p38 defines the common senescence-signalling pathway. Genes Cells, 8(2):131-144 (2003). [PubMed]
Takata T. and F. Ishikawa. Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem. Biophys. Res. Commun., 301(1):250-257 (2003). [PubMed]
Miyoshi T., M. Sadaie, J. Kanoh and F. Ishikawa. Telomeric DNA ends are essential for the localization of Ku at telomeres in fission yeast. J. Biol. Chem., 278(3):1924-1931 (2003). [PubMed]
Sakai H., T. Urano, K. Ookata, Kim M.H., Y. Hirai, M. Saito, Y. Nojima and F. Ishikawa. MBD3 and HDAC1, two components of the NuRD complex, are localized at Aurora-A-positive centrosomes in M phase. J. Biol. Chem., 277(50):48714-48723 (2002). [PubMed]
Hoque M. T. and F. Ishikawa. Cohesin defects lead to premature sister chromatid separation, kinetochore dysfunction and spindle-assembly checkpoint activation. J. Biol. Chem., 277(44):42306-42314 (2002). [PubMed]
Kim M. H., X. Yuan, S. Okumura and F. Ishikawa. Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs. Biochem. Biphys. Res. Commun., 296(5):1372-1377 (2002). [PubMed]
Saito, M. and F. Ishikawa. The mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2. J. Biol. Chem., 277(38):35434-35439 (2002). [PubMed]
Haraguchi M., H. Tsujimoto, M. Fukushima, I. Higuchi, H. Kuribayashi, H. Utsumi, A. Nakayama, Y. Hashizume, J. Hirato, H. Yoshida, H. Hara, S. Hamano, H. Kawaguchi, T. Furukawa, K. Miyazono, F. Ishikawa, H. Toyoshima, T. Kaname, M. Komatsu, Z.S. Chen, T. Gotanda, T. Tachiwada, T. Sumizawa, K. Miyadera, M. Osame, H. Yoshida, T. Noda, Y. Yamada and S. Akiyama. Targeted deletion of both thymidine phosphorylase and uridine phosphorylase and consequent disorders in mice. Mol. Cell. Biol., 22(14):5212-5221 (2002). [PubMed]
Kanzaki Y., F. Onoue, F. Ishikawa and T. Ide. Telomerase rescues the expression levels of keratinocyte growth factor and insulin-like growth factor-II in senescent human fibroblasts. Exp. Cell Res., 279(2):321-329 (2002). [PubMed]
Yago M., R. Ohki, S. Hatakeyama, T. Fujita and F. Ishikawa. Variant forms of upstream stimulatory factors (USFs) control the promoter activity of hTERT, the human gene encoding the catalytic subunit of telomerase. FEBS Lett., 520(1-3):40-46 (2002). [PubMed]
Katahira M., Y. Miyanoiri, Y. Enokizono, G. Matsuda, T. Nagata, F. Ishikawa and S. Uesugi. Structure of the C-terminal RNA-binding domain of hnRNP D0 (AUF1), its interactions with RNA and DNA, and change in backbone dynamics upon complex formation with DNA. J. Mol. Biol., 311(5):973-988 (2001). [PubMed]
Yamaguchi, T., R. Yamada, A. Tomikawa, K. Shudo, M. Saito, F. Ishikawa and M. Saneyoshi. Inhibition of human telomerase by L-enantiomers of natural 2'-deoxyribonucleoside 5'-triphosphates. Nucleosides Nucleotides Nucleic Asids, 20(4-7):1243-1246 (2001). [PubMed]
Yamaguchi T., Y. Takayama, M. Saito, F. Ishikawa and M. Saneyoshi. Telomerase-inhibitory effects of the triphosphate derivatives of some biologically active nucleosides. Nucleic Acids Res. Suppl., (1):211-212(2001). [PubMed]
Kanoh J. and F. Ishikawa. spRap1 and spRif1, recruited to telomeres by Taz1, are essential for telomere function in fission yeast.Curr. Biol., 11(20):1624-1630 (2001). [PubMed]
Kuramoto M., K. Ohsumi, T. Kishimoto and F. Ishikawa. Identification and analyses of the Xenopus TERT gene that encodes the catalytic subunit of telomerase. Gene, 277(1-2):101-110 (2001). [PubMed]
Ohki R., T. Tsurimoto and F. Ishikawa. In vitro reconstitution of the end replication problem. Mol. Cell. Biol., 21(17):5753-5766 (2001). [PubMed]
Ohno J., Y. Horio, Y. Sekido, Y. Hasegawa, M. Takahashi, J. Nishizawa, H. Saito, F. Ishikawa and K. Shimokata. Telomerase activation and p53 mutations in urethane-induced A/J mouse lung tumor development. Carcinogenesis, 22(5):751-756 (2001). [PubMed]
Hoque M. T. and F. Ishikawa. Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. J. Biol. Chem., 276(7):5059-5067 (2001). [PubMed]
Tatematsu K. I., T. Yamazaki and F. Ishikawa. MBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phase. Genes Cells, 5(8):677-688 (2000). [PubMed]
Yamaguchi T., M. Kawarai, Y. Takeshita, F. Ishikawa, and M. Saneyoshi.Inhibition of human telomerase by nucleotide analogues bearing a hydrophobic group. Nucleic Acids Symp. Ser., (44):175-176 (2000). [PubMed]
Yamaguchi T., R. Yamada, A. Tomikawa, K. Shudo, M. Saito, F. Ishikawa and M. Saneyoshi. Recognition of 2'-deoxy-l-ribonucleoside 5'-triphosphates by human telomerase. Biochem. Biophys. Res. Commun., 279(2):475-481 (2000). [PubMed]
Kawakami Y., M. Kitamoto, T. Nakanishi, W. Yasui, E. Tahara, J. Nakayama, F. Ishikawa, H. Tahara, T. Ide and G. Kajiyama. Immuno-histochemical detection of human telomerase reverse transcriptase in human liver tissues. Oncogene, 19(34):3888-3893 (2000). [PubMed]
Yuan X., S. Ishibashi, S. Hatakeyama, M. Saito, J. Nakayama, R. Nikaido, T. Haruyama, Y. Watanabe, H. Iwata, M. Iida, H. Sugimura, N. Yamada and F. Ishikawa. Presence of telomeric G-strand tails in the telomerase catalytic subunit TERT knockout mice. Genes Cells, 4(10):563-572 (1999). [PubMed]
Matsuura A., T. Naito and F. Ishikawa. Genetic control of telomere integrity in Schizosaccharomyces pombe: rad3+ and tel1+ are parts of two regulatory networks independent of the downstream protein kinases chk1+ and cds1+. Genetics, 152(4):1501-1512 (1999). [PubMed]
Yasui W., E. Tahara, H. Tahara, J. Fujimoto, K. Naka, J. Nakayama, F. Ishikawa, T. Ide, and E. Tahara. Immunohistochemical detection of human telomerase reverse transcriptase in normal mucosa and precancerous lesions of the tomach. Jpn. J. Cancer Res., 90(6):589-595 (1999). [PubMed]
Nagata T., Y. Kurihara, G. Matsuda, J. Saeki, T. Kohno, Y. Yanagida, F. Ishikawa, S. Uesugi, and M. Katahira. Structure and interactions with RNA of the N-terminal UUAG-specific RNA-binding Domain of hnRNP D0. J. Mol. Biol., 287(2):221-237 (1999). [PubMed]
Tahara H., W. Yasui, E. Tahara, J. Fujimoto, K. Ito, K. Tamai, J. Nakayama, F. Ishikawa, E. Tahara and T. Ide.Immuno-histochemical detection of human telomerase catalytic component, hTERT, in human colorectal tumor and non-tumor tissue sections. Oncogene, 18(8):1561-1567 (1999). [PubMed]
Hatakeyama S., M. Osawa, M. Omine and F. Ishikawa. JTB: a novel membrane protein gene at 1q21 rearranged in a jumping translocation. Oncogene, 18(12):2085-2090 (1999). [PubMed]
Yamada M., N. Hayatsu, A. Matsuura and F. Ishikawa.Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y' element is induced in survivors defective for telomerase. J. Biol. Chem., 273(50):33360-33366 (1998). [PubMed]
Yasui W., H. Tahara, E. Tahara, J. Fujimoto, J. Nakayama, F. Ishikawa, T. Ide and E. Tahara. Expression of telomerase catalytic component, telomerase reverse transcriptase, in human gastric carcinomas. Jpn. J. Cancer Res. (Gann), 89(11):1099-1103 (1998). [PubMed]
Naito T., A. Matsuura and F. Ishikawa. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat. Genet., 20(2):203-206 (1998). [PubMed]
Hatakeyama S., K. Fujita, M. Omine and F. Ishikawa. Shortened telomeres involved in a case with a jumping translocation at 1q21. Blood, 91(5):1514-1519 (1998). [PubMed]
Nakayama J., H. Tahara, E. Tahara, M. Saito, K. Ito, H. Nakamura, T. Nakanishi, E. Tahara, T. Ide and F. Ishikawa. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat. Genet., 18(1):65-68 (1998). [PubMed]
Saito T., Y. Matsuda, T. Suzuki, A. Hayashi, X. Yuan, M. Saito, J. Nakayama, T. Hori and F. Ishikawa. Comparative gene mapping of the human and mouse TEP1 genes, that encode one protein component of telomerases. Genomics, 46(1):46-50 (1997). [PubMed]
Hatakeyama S. and F. Ishikawa. ICE: a novel and efficient method for isolation of chromosomal ends. Genet. Anal., 14(2):45-46 (1997). [PubMed]
Nakayama J., M. Saito, H. Nakayama, A. Matsuura and F. Ishikawa. TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell, 88(6):875-884 (1997). [PubMed]
Tatematsu K., J. Nakayama, M. Danbara, S. Shionoya, H. Sato, M. Omine and F. Ishikawa. A novel quantative 'stretch PCR assay', that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias. Oncogene, 13(10):2265-2274 (1996). [PubMed]
Ikeda-Nishizawa Y., Y. Yazaki, H. Hirai and F. Ishikawa. Spatial progression of DNA strand breaks in apoptotic HL-60 cells. Bioimages, 4(1):63-72 (1996).
Kajita Y., E. Kobatake, F. Ishikawa and M. Aizawa. Bioluminescent detection of RNA with sequence-specificity using RNA binding protein-luciferase fusion protein. J. Biotechnol., 43(1):63-70 (1995). [PubMed]
Kajita Y., J. Nakayama, M. Aizawa and F. Ishikawa. The UUAG-specific RNA binding protein, heterogeneous nuclear ribonucleo protein D0. Common modular structure and binding properties of the 2xRBD-Gly family. J. Biol. Chem., 270(38):22167-22175 (1995). [PubMed]
Ishikawa F., M. Matunis, G. Dreyfuss and T. Cech. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol. Cell. Biol., 13(7):4301-4310 (1993). [PubMed]