RESEARCH
This laboratory is interested in understanding the mutual interactions between the genome and the surrounding environment.
For example, how do organisms preserve their internal resources until their surrounding conditions are suitable for reproduction? How do they prevent mortal pathologies such as cancers until they complete growth and reproduction? Is aging a consequence of damage accumulation caused by fluctuating harsh environments? Does the ever changing microenvironments in the wild in contrast to those persistently cultivated in laboratories, play a significant role, if any, in the life history of an organism in nature?
To address these questions, our team branches into three distinct research groups. A brief sketch of each group is given below.
For example, how do organisms preserve their internal resources until their surrounding conditions are suitable for reproduction? How do they prevent mortal pathologies such as cancers until they complete growth and reproduction? Is aging a consequence of damage accumulation caused by fluctuating harsh environments? Does the ever changing microenvironments in the wild in contrast to those persistently cultivated in laboratories, play a significant role, if any, in the life history of an organism in nature?
To address these questions, our team branches into three distinct research groups. A brief sketch of each group is given below.
What we investigate
Telomere
The telomere refers to the chromatin at the two termini of linear genomic DNA.
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Low-dose Stress
We have understood well how cells are killed by high-level or lethal stresses at the molecular level.
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Transposon
Recently, our laboratory is interested in investigating transposable elements or "jumping genes" that comprise ~45% of the human genome.
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Senescence
The maintenance of tissue homeostasis and integrity is integral to a reproductive success.
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